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1. During bacteriological examination of smears of preparations of the patient with gingivitis from the purulent discharge taken by the dentist for the study, cocci within the leukocytes were found, as well as outside cells in the form of clusters. Justify the phenomenon found in the preparations. Formulate this phenomenon, taking into account the morphology of the microorganism, the properties of the protective cells of the patient with gingivitis. What microorganisms are found inside the leukocytes from the test smear being separated?
2. During a bacterioscopy of a smear from a patient with pneumonia, gram (-) cocci within the leukocytes were found, and elongated cocci resembling a candle flame, outside the leukocytes. Determine what kind of phenomenon it is? What microorganisms are located inside and outside the white blood cells?
Tests:
1. Cytocidal cells that destroy target cells
A) T-helpers
B) T-killers
C) T-effectors
D) T-suppressors
E) B-lymphocytes
2. Various acids of sebaceous and sweat glands of the skin, possessing antimicrobial properties, are the factors of protection
A) biological
B) immunological
C) physico-chemical
D) mechanical
E) specific
3. The humoral factor, competing with microorganisms for the metabolites necessary for them, without which the pathogens can not reproduce
A) interferon
B) B-lysine
C) transferrin
D) fibronectin
E) complement
4. The humoral factor interacting with the surface of microorganisms, contributing to their phagocytosis, fulfills the role of opsonins
A) B-lysine
B) fibronectin
C) transferrin
D) complement
E) interferon
5. Large granulosoderzhaschie lymphocytes, which have a cytotoxic effect against foreign cells
A) monocytes
B) leukocytes
C) natural killers
D) T-killers
E) platelets
6. Cells of mesoderm origin, absorbing and digesting microorganisms
A) phagocytes
B) red blood cells
C) platelets
D) T-suppressors
E) T-helpers
7. The humoral factor of nonspecific resistance of the organism
A) microphages
B) Properdin protein
C) T-killers
D) Hydrochloric acid of gastric juice
E) macrophages
8. The ratio of phagocytic parameters obtained with immune and non-immune serum is called the index
A) leukocyte
B) phagocytic
C) opsonic
D) opsonophagocytic
E) lymphocytic
9. Complex complex of proteins of serum, reacting with each other in a certain sequence
A) transferrin
B) B-lysine
C) complement
D) fibronectin
E) interferon
10. Biological active substances produced by macrophages, often found in saliva and tears
A) immunoglobulins
B) peroxidase
C) interleukins
D) complement proteins
E) lysozyme
Lesson№ 15.
1. Topic: Specific factors of immunity. Antigens and antibodies.
2. Aim: To master the factors of immunity and evaluation of the immunological status of the human body.
3. Objectives: To give an idea of the methods of assessing the T and B-system of human immunity.
4. Main questions of the topic:
1. Give a definition of the term "antigen" and list the main properties of antigens.
2. Classification of antigens.
3. Defective antigens.
4. Antigens of the human body
5. Antigens of the main tissue compatibility complex.
6. Antigens of microorganisms.
7. Give a definition of the concept of "antibody", their functions.
8. The chemical nature and structure of antibodies or immunoglobulins.
9. Classes of immunoglobulins, their main characteristics, differences and features.
10. Antiglobulin antibodies.
11. Anti-idiotype antibodies.
12. Immunological memory.
13. Immunological tolerance.
5. Methods of learning and teaching: Discussion
6. Literature:
1. Medical microbiology, virologists and immunology. Ed. Academician of RAMS Zverev VV, Professor Boychenko MN - Moscow, GEOTAR-Media, 2010. - 1t. - 900 b.
2. Medical microbiology, virology and immunology. Ed. Vorobyeva A.A. - Moscow: MIA, 2008. - 690 p.
3. Medical microbiology, immunology and virology: a textbook for honey. universities. Ed. Korotyaeva AI, Babicheva SA - 5-еизд., Испр.и доп. - SPb .: SpecLit, 2012. - 760 pp. : ill.
4. Medical microbiology, virology, immunology. Ed. Borisova LB ..- M .: MIA, 2006.-734 p.
5. Medical Microbiology / Ch. Ed. Pokrovsky VI, Pozdeev O.K. - Moscow: GEOTAR MEDICINE, 2007.
6. Atlas on medical microbiology, virology and immunology: atlas / ed .: AS Bykov, AA Vorob'ev, VV Zverev. - 2 nd ed., Ext. - M .: Honey. inform. agency, 2008. - 272 p .: ill.
7. A guide to practical exercises on medical microbiology, virology and immunology. Ed. Tetz V.V. -М.: Медицина, 2002.-352 с.
8. Computer program "Diamorph" - "Medical microbiology" - atlas-guidance on bacteriology of mycology, protozoology and virology, edited by acad. prof. Vorobyeva A.A.
9. The determinant of bacteria Berdzhi / Ed. D. Houlta, N. Krig, P. Snitai et al., Moscow: Mir, 1997. - In 2 volumes.
In english language
1. Microbiology Fundamentals: A Clinical Approach - Standalone book 2nd Edition.
2. Richard V Georing, Hazel M Docrell, Mark Zukerman, Derek Wakelin, Ivan M Roit, Cedric Mims, Peter L Chiodini «Medical Microbiology», 4th Edithion, 2008, UK, p.656.
3. Jacquelyn G Black «Microbiology», 7 th ,WILEY, 2010, p. 846.
4. Patric R Muray, Ken S Rosenthal, Michael F Pfaller «Medical Microbiology», 5th Edithion, 2008, p. 962.
Electronic resources:
1. Medicine 3 year [Electrones resource]: a course of lectures. - Electron. text dan. (24.0 MB). - M: Publishing house "Balance", 2005. -1 эл. opt. disk (CD-ROM).
2. Medical microbiology ATLAS - a guide to bacteriology, mycology, protozoology and virology [Electron resource]: for stud. and doctors / ed. A.S. Bykov. -M., 2001. -1 el. opt. disk (CD-ROM).
3. Workshop for laboratory studies on general microbiology [Electron resource]: teaching method. Manual / R.T. Dzhanabaev [et al.] -Sh., 2004. -1 e. opt. disk (CD-ROM).
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